Metal-insulator transition in a weakly interacting many-electron system with localized single-particle states

We consider low-temperature behavior of weakly interacting electrons in disordered conductors in the regime when all single-particle eigenstates are localized by the quenched disorder. We prove that in the absence of coupling of the electrons to any external bath dc electrical conductivity exactly vanishes as long as the temperatute $T$ does not exceed some finite value $T_c$. At the same time, it can be also proven that at high enough $T$ the conductivity is finite. These two statements imply that the system undergoes a finite temperature Metal-to-Insulator transition, which can be viewed as Anderson-like localization of many-body wave functions in the Fock space. Metallic and insulating states are not different from each other by any spatial or discrete symmetries. We formulate the effective Hamiltonian description of the system at low energies (of the order of the level spacing in the single-particle localization volume). In the metallic phase quantum Boltzmann equation is valid, allowing to find the kinetic coefficients. In the insulating phase, $T<T_c$, we use Feynmann diagram technique to determine the probability distribution function for quantum-mechanical transition rates. The probability of an escape rate from a given quantum state to be finite turns out to vanish in every order of the perturbation theory in electron-electron interaction. Thus, electron-electron interaction alone is unable to cause the relaxation and establish the thermal equilibrium. As soon as some weak coupling to a bath is turned on, conductivity becomes finite even in the insulating phase

Limited Lifespan of Fragile Regions in Mammalian Evolution

An important question in genome evolution is whether there exist fragile regions (rearrangement hotspots) where chromosomal rearrangements are happening over and over again. Although nearly all recent studies supported the existence of fragile regions in mammalian genomes, the most comprehensive phylogenomic study of mammals (Ma et al. (2006) Genome Research 16, 1557-1565) raised some doubts about their existence. We demonstrate that fragile regions are subject to a "birth and death" process, implying that fragility has limited evolutionary lifespan. This finding implies that fragile regions migrate to different locations in different mammals, explaining why there exist only a few chromosomal breakpoints shared between different lineages. The birth and death of fragile regions phenomenon reinforces the hypothesis that rearrangements are promoted by matching segmental duplications and suggests putative locations of the currently active fragile regions in the human genome

Quantum correction to the Kubo formula in closed mesoscopic systems

We study the energy dissipation rate in a mesoscopic system described by the parametrically-driven random-matrix Hamiltonian H[\phi(t)] for the case of linear bias \phi=vt. Evolution of the field \phi(t) causes interlevel transitions leading to energy pumping, and also smears the discrete spectrum of the Hamiltonian. For sufficiently fast perturbation this smearing exceeds the mean level spacing and the dissipation rate is given by the Kubo formula. We calculate the quantum correction to the Kubo result that reveals the original discreteness of the energy spectrum. The first correction to the system viscosity scales proportional to v^{-2/3} in the orthogonal case and vanishes in the unitary case.Comment: 4 pages, 3 eps figures, REVTeX

Transition to an Insulating Phase Induced by Attractive Interactions in the Disordered Three-Dimensional Hubbard Model

We study numerically the interplay of disorder and attractive interactions for spin-1/2 fermions in the three-dimensional Hubbard model. The results obtained by projector quantum Monte Carlo simulations show that at moderate disorder, increasing the attractive interaction leads to a transition from delocalized superconducting states to the insulating phase of localized pairs. This transition takes place well within the metallic phase of the single-particle Anderson model.Comment: revtex, 4 pages, 3 figure

Classification of a supersolid: Trial wavefunctions, Symmetry breakings and Excitation spectra

A state of matter is characterized by its symmetry breaking and elementary excitations. A supersolid is a state which breaks both translational symmetry and internal $U(1)$ symmetry. Here, we review some past and recent works in phenomenological Ginsburg-Landau theories, ground state trial wavefunctions and microscopic numerical calculations. We also write down a new effective supersolid Hamiltonian on a lattice. The eigenstates of the Hamiltonian contains both the ground state wavefunction and all the excited states (supersolidon) wavefunctions. We contrast various kinds of supersolids in both continuous systems and on lattices, both condensed matter and cold atom systems. We provide additional new insights in studying their order parameters, symmetry breaking patterns, the excitation spectra and detection methods.Comment: REVTEX4, 19 pages, 3 figure

Technologies of sleep research

Sleep is investigated in many different ways, many different species and under many different circumstances. Modern sleep research is a multidisciplinary venture. Therefore, this review cannot give a complete overview of all techniques used in sleep research and sleep medicine. What it will try to do is to give an overview of widely applied techniques and exciting new developments. Electroencephalography has been the backbone of sleep research and sleep medicine since its first application in the 1930s. The electroencephalogram is still used but now combined with many different techniques monitoring body and brain temperature, changes in brain and blood chemistry, or changes in brain functioning. Animal research has been very important for progress in sleep research and sleep medicine. It provides opportunities to investigate the sleeping brain in ways not possible in healthy volunteers. Progress in genomics has brought new insights in sleep regulation, the best example being the discovery of hypocretin/orexin deficiency as the cause of narcolepsy. Gene manipulation holds great promise for the future since it is possible not only to investigate the functions of different genes under normal conditions, but also to mimic human pathology in much greater detail

The Cholecystectomy As A Day Case (CAAD) Score: A Validated Score of Preoperative Predictors of Successful Day-Case Cholecystectomy Using the CholeS Data Set

Background Day-case surgery is associated with significant patient and cost benefits. However, only 43% of cholecystectomy patients are discharged home the same day. One hypothesis is day-case cholecystectomy rates, defined as patients discharged the same day as their operation, may be improved by better assessment of patients using standard preoperative variables. Methods Data were extracted from a prospectively collected data set of cholecystectomy patients from 166 UK and Irish hospitals (CholeS). Cholecystectomies performed as elective procedures were divided into main (75%) and validation (25%) data sets. Preoperative predictors were identified, and a risk score of failed day case was devised using multivariate logistic regression. Receiver operating curve analysis was used to validate the score in the validation data set. Results Of the 7426 elective cholecystectomies performed, 49% of these were discharged home the same day. Same-day discharge following cholecystectomy was less likely with older patients (OR 0.18, 95% CI 0.15–0.23), higher ASA scores (OR 0.19, 95% CI 0.15–0.23), complicated cholelithiasis (OR 0.38, 95% CI 0.31 to 0.48), male gender (OR 0.66, 95% CI 0.58–0.74), previous acute gallstone-related admissions (OR 0.54, 95% CI 0.48–0.60) and preoperative endoscopic intervention (OR 0.40, 95% CI 0.34–0.47). The CAAD score was developed using these variables. When applied to the validation subgroup, a CAAD score of ≤5 was associated with 80.8% successful day-case cholecystectomy compared with 19.2% associated with a CAAD score >5 (p < 0.001). Conclusions The CAAD score which utilises data readily available from clinic letters and electronic sources can predict same-day discharges following cholecystectomy